Hypothetical model depicting feedback regulation between sch9 and the v-atpase.... As protein hydrolysis and amino acid uptake are regulated by vacuolar acidity, a feedback mechanism onto Sch9 activity is provided through amino acid sensing by the EGO complex (EGOC) and subsequent regulation of TORC1 activity....
Upstream regulation of yeast tor complexes... Recent studies identified the EGO complex as intermediary component of the amino acid sensing pathway....
Ego3 functions as a homodimer to mediate the interaction between gtr1-gtr2 and ego1 in the ego complex to activate torc1 SummaryThe yeast EGO complex, consisting of Gtr1, Gtr2, Ego1, and Ego3, localizes to the endosomal and vacuolar membranes and plays a pivotal role in cell growth and autophagy regulation through...
Ego3 functions as a homodimer to mediate the interaction between gtr1-gtr2 and ego1 in the ego complex to activate torc1The yeast EGO complex, consisting of Gtr1, Gtr2, Ego1, and Ego3, localizes to the endosomal and vacuolar membranes and plays a pivotal role in cell growth and autophagy regulation through...
