Local anesthetics lidocaine and chloroprocaine are not used nowadays because the action time for chloroprocaine is too short and repeated doses of lidocaine are found to cause tachyphylaxis.
Unexpectedly, the intrathecal administration in repeated doses of chloroprocaine does not increase the neurotoxicity of this drug in statistically significant manner.
Epidurals are categorised under a class of drugs known as local anaesthetics, which include the likes of bupivacaine, chloroprocaine, or lidocaine.
The present invention concerns a new use for a composition comprising chloroprocaine HCI, and in particular its use for the manufacture of a drug for intrathecal narcosis.
The present invention also concerns a new composition comprising chloroprocaine HCI, being particularly suited to this new use, as well as a new method for manufacturing said composition.
There is only one drug, 2-chloroprocaine that is metabolized in the fetal blood so rapidly that even in acidosis, substantial accumulation in the fetus is avoided.
Since ester-type local anesthetics are hydrolyzed by plasma cholinesterase produced by the liver, Chloroprocaine should be used cautiously in patients with hepatic disease.
Since ester-type local anesthetics are hydrolyzed by plasma cholinesterase produced by the liver, chloroprocaine should be used cautiously in patients with hepatic disease.
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