The Fc-antigen fusion proteins bind Fc receptors on the surface of antigen presenting cells, thereby targeting the antigen to the antigen presenting cells in the mammal.

The conjugate antibody molecules deliver the antigen to antigen presenting cells to produce an enhanced immune response to a host immunized therewith.

The modified soluble protein antigen comprises an added peptidic sequence which facilitates entry of the modified antigen into antigen presenting cells (APC).

The conjugate exhibits immunosuppressive activity on T cells, B cells or antigen presenting cells.

The conjugate antibody retained specificity for antigen presenting cells and contained the antigen moiety.

Thus, in one aspect, this invention provides a method of recruiting antigen presenting cells (APCs) to a predetermined site in a subject.

Methods of using the modified microbes for the loading, activation, and/or maturation of antigen-presenting cells are also provided.

Cells of the immune system get activated when membrane receptors bind to cognate antigen on the surface of antigen presenting cells.

T-cell responses are initiated via contact with MHC/peptide complexes on antigen presenting cells (APCs).

The methods involve treating the graft with a molecule which binds to a co-stimulatory protein of antigen-presenting cells.

An effective amount of an antigen presenting cell (APC) recruitment factor can be administered to the subject to recruit APC to the locus of the target cell.

Vaccine compositions comprising the modified microbes and/or the antigenpresenting cells and methods of using the vaccines are also provided.

Antigen-presenting cells and isolated CTLs that target such peptides, as well as methods for inducing the antigen-presenting cell, or CTL are also provided.

The HSPs can also be used to activate antigen presenting cells which are then introduced into a subject in conjunction with a vaccine.

Optionally, the methods further comprise administering antigen presenting cells sensitized with complexes of hsps noncovalently bound to an antigenic molecule.