Dictionnaire français - anglais

Cette invention concerne des procédés de chargement dans une cellule présentant des antigènes d'un ou de plusieurs antigènes.

Methods for loading an antigen-presenting cell with one ore more antigens are disclosed.

santé - wipo.int
L'invention concerne également des méthodes de traitement et de prévention d'une maladie chez un sujet au moyen d'une cellule présentant des antigènes qui a reçu un ou plusieurs antigènes par électroporation.

Methods for the treatment and prevention of a disease in a subject using an antigen-presenting cell that has been electroporated with a composition of one or more antigens.

santé - wipo.int
L'invention concerne aussi des procédés pour activer une cellule présentant des antigènes et provoquer une réponse immune en induisant une activité CD40 sans prostaglandine E2.

Also provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing CD40 activity without prostaglandin E2.

santé - wipo.int
L'invention concerne des procédés pour activer une cellule présentant des antigènes et provoquer une réponse immune en induisant une activité d'un récepteur de reconnaissance de structures et une activité CD40.

Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity.

santé - wipo.int
Immune response gene function correlates with the expression of an ia antigen. ii. a quantitative deficiency in a(e):e(a), complex expression causes a corresponding defect in antigen-presenting cell function... These functional data, in concert with the biochemical and serological data in the accompanying report, are consistent with the molecular model for Ir gene complementation in which appropriate two-chain Ia molecules function at the antigen-presenting cell (APC) surface as restriction elements....
santé / production - core.ac.uk - PDF: www.pubmedcentral.nih.gov
Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics... The hypothesis is that PLP-BPI binds simultaneously to major histocompatibility complex-II and intercellular adhesion molecule-1 on the antigen-presenting cell (APC) and inhibits the formation of the immunological synapse during T-cell and APC interactions....
Ia expression by vascular endothelium is inducible by activated t cells and by human gamma-interferonT helper cells recognize exogenous antigens in association with class II histocompatibility antigens (Ia antigens) on the surface of an antigen-presenting cell (APC) 1 (reviewed in reference 1)....
cellule présentant des antigènes
santé - iate.europa.eu

Publications scientifiques

Expression and manipulation of the apc-β-catenin pathway during peripheral neuron regeneration... β-catenin was expressed in neuronal nuclei, neuronal cytoplasm and also in perineuronal satellite cells....
santé - core.ac.uk - PDF: link.springer.com
Tumorigenic fragments of apc cause dominant defects in directional cell migration in multiple model systems... Here we show that, in three distinct experimental model systems, expression of an N-terminal fragment of APC (N-APC) results in loss of directionality, but not speed, of cell motility independently of changes in β-catenin regulation....
santé / détérioration de l'environnement - core.ac.uk - PDF: doaj.org
Identification of 5 novel germline apc mutations and characterization of clinical phenotypes in japanese patients with classical and attenuated familial adenomatous polyposis.... An attenuated form of FAP (AFAP) is diagnosed based on a milder colorectal phenotype, and the colorectal phenotype of (A)FAP has been linked to germline APC mutations....
santé - core.ac.uk - PDF: hikumano.hama-med.ac.jp
Antitumor activity of the mek inhibitor trametinib on intestinal polyp formation in apc[δ716] mice involves stromal cox-2Extracellular signal-regulated kinase is an MAPK that is most closely associated with cell proliferation, and the MEK/ERK signaling pathway is implicated in various human cancers....
santé - core.ac.uk - PDF: repository.kulib.kyoto-u.ac.jp
A target-selected apc-mutant rat kindred enhances the modeling of familial human colon cancer... We have investigated whether a rat model carrying a knockout allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer of the human more closely than existing murine models....
santé / technologie et réglementation technique - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Traductions en contexte français - anglais

Les peptides présents dans l'exosome de la molécule de CMH peuvent être traités par la cellule présentant des antigènes dont est dérivé l'exosome.

The peptides present in the exosome in the MHC molecule may be processed by the antigen presenting cell from which the exosome is derived.

santé - wipo.int
Une composition thérapeutique peut éventuellement comprendre une cellule présentant des antigènes qui exprime HPP14 (une partie, ou un autre variant de celui-ci), ou une cellule T qui est spécifiques des cellules exprimant cette protéine.

Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses HPP14 (or a portion or other variant thereof), or a T cell that is specific for cells expressing such a protein.

santé - wipo.int


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