Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide.Rat colonic circular muscle, main target of otilonium bromide (OB) spasmolytic activity, is subdivided in an inner and outer portion....
Histamine causes influx via t-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions.... In accordance with the relief it offers some inflammatory bowel disease patients, otilonium bromide, a gut-impermeable inhibitor of T-type (and L-type) VGCCs and muscarinic ACh receptors, efficiently inhibited the [Ca] responses induced by histamine plus ACh...
Preparation and characterization of reconstructed small intestinal brush border membranes for surface plasmon resonance analysis... The performance of BBMVs immobilized was evaluated by their interac-tion with otilonium bromide and bile salts....
T-type ca2+ channel modulation by otilonium bromide... Otilonium bromide, an antispasmodic, has previously been shown to inhibit L-type Ca2+ channels and colonic contractile activity....
