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bimakalim

santé / chimie - iate.europa.eu
Le flux de bimakalim libéré par le dispositif à travers la peau est supérieur à 0,1 νg/cm2/hr.

The skin flux of bimakalim from the patches is greater than 0.1 νg/cm2/hr.

santé - wipo.int
Pharmacological investigation in a swine model of chronic left ventricular dysfunction... The results of bimakalim are compared tothe nicotinamide derivative nicorandil, which in addition to their nitrate-like properties,also possess potassium channel activator properties (Taira,...
général - core.ac.uk - PDF: www.loc.gov
K(atp) channels and ‘border zone' arrhythmias: role of the repolarization dispersion between normal and ischaemic ventricular regions... In order to investigate the role of K(ATP) channel activation and repolarization dispersion on the ‘border zone' arrhythmias induced by ischaemia-reperfusion, the effects of glibenclamide and bimakalim, agents modifying action potential (AP) duration, were studied in an in vitro model of myocardial ‘border zone'....
Adenosine triphosphate–dependent potassium channel modulation and cardioplegia-induced protection of human atrial muscle in an in vitro model of myocardial stunning ... In an organ bath at 37°C, the preparations were subjected to 60 minutes of hypoxia at a high stimulation rate either in Tyrode solution (control, n = 17) or in St Thomas’ Hospital solution without additives (n = 6) or associated with 100 nmol/L bimakalim (n = 7) or 1 μmol/L glibenclamide (n = 7), followed by 60 minutes of reoxygenation and 15 minutes of positive inotropic stimulation with 1 μmol/L dobutamine....


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