Comparison of the pharmacodynamics of biapenem in bronchial epithelial lining fluid in healthy volunteers given half-hour and three-hour intravenous infusions... The objective of this study was to compare the PK/PD parameters in bronchial epithelial lining fluid (ELF) of biapenem given as 0.5-h...
In vitro activity of biapenem against clinical isolates of gram-positive and gram-negative bacteria.The in vitro activity of biapenem, a new carbapenem previously designated L-627, was compared with those of imipenem and several other antimicrobial agents against 771 clinical bacterial isolates....
Formation of the bicyclic derivative of biapenem.... QM/MM optimized model of the active site of CphA in complex with hydrolyzed biapenem (“Conformation A” in the metadynamics analysis of the hydroxyethyl group rotations described later on)....
In vitro activity of biapenem (l-627), a new carbapenem, against anaerobes.We tested 441 clinical strains of anaerobes by using a broth microdilution method to determine the in vitro activity of biapenem for comparison with those of other agents....
