An additional 23 ORFs flank the disclosed enduracidin biosynthetic gene cluster.
An enduracidin gene cluster is located within a 116 kilobases genetic locus and includes 25 open reading frames (ORFs).
The isolated biosynthetic gene cluster serves as a substrate for bioengineering of antibiotic structures.
Enduracidin analogs and a method for producing them by manipulation of the enduracidin gene cluster and specific genes thereinare also disclosed.
This invention relates to the gene cluster for angucycline biosynthesis, derived from Streptomyces, and use of the genes therein to obtain antibiotics for drug screening.
These genes are organized into a discrete cluster at chromosomal location 1q22 (the “immune gene complex”) and span about 700 kb of DNA.
Another cluster of GPCR genes is located at chromosomal band 11q24.
These genes are expressed predominantly in pancreatic tissue, establishing this region of chromosome 11 as a unique gene complex involved in pancreatic function.
A cluster of transmembrane and GPCR-type receptor genes is also located at chromosomal band 11q12.2.
The invention also relates to an HCC specific cluster as a unique diagnostic agent for HCC.
For example, the invention relates to a group of genes encoding GPCR-like receptors that are involved in the function and activity of the immune system.
It provides polynucleotides for the gene cluster of enzymes involved in the biosynthesis of cycloclavin as well as vectors and host cells comprising such polynucleotides.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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