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azidothymidine

santé - iate.europa.eu
[18] AZT : azidothymidine, vendue principalement sous les noms Zidovudine et Retrovir.

(1) (AZT stands for azidothymidine and is marketed under the names Zidovudine or Retrovir.)

général - CCMatrix (Wikipedia + CommonCrawl)
La zidovudine (azidothymidine, AZT ou ZDV) est un médicament antirétroviral, le premier utilisé pour le traitement de l'infection par le VIH.

Zidovudine (INN) or azidothymidine (AZT) is an antiretroviral drug, the first one approved for treatment of HIV.

général - CCMatrix (Wikipedia + CommonCrawl)
La zidovudine (azidothymidine, AZT ou ZDV) est un médicament antirétroviral, le premier utilisé pour le traitement de l'infection par le VIH.

Zidovudine (INN) or azidothymidine (AZT) is an antiretroviral drug, the first one approved for treatment of HIV.

général - CCMatrix (Wikipedia + CommonCrawl)
CMX157 On a observé une très forte activité antivirale contre le virus XMRV in vitro, avec une EC50 environ 20 fois plus puissant que le azidothymidine médicament anti-rétroviraux (AZT) et 800 fois plus puissant que le ténofovir.

CMX157 was observed to have highly potent antiviral activity against XMRV in vitro, with an EC50 approximately 20-fold more potent than the anti-retroviral drug azidothymidine (AZT) and 800-fold more potent than tenofovir.

général - CCMatrix (Wikipedia + CommonCrawl)
azidothymidine
santé - iate.europa.eu
santé - iate.europa.eu
Rotterdam, and academic hospital. maastricht. and leijenburg...scores;:.60 were enrolled in a multicenter, randomized, controlled trial that compared zidovudine monotherapy and combina-tion therapy for 48 weeks with zidovudine and interferon-a (IFN-a)....
santé - core.ac.uk - PDF: jid.oxfordjournals.org
Penetration of zidovudine and 3'-fluoro-3'-deoxythymidine into the brain, muscle tissue, and veins in cynomolgus monkeys: relation to antiviral action.... A dose of 25 mg of zidovudine or 3'-fluoro-3'-deoxythymidine (FLT) per kg was administered subcutaneously to each of three animals....
Impact of hiv infection and zidovudine therapy on rbc parameters and urine methylmalonic acid levels... The aim of this study was to investigate the impact of HIV infection and zidovudine on red blood cells (RBC) parameters and urine methylmalonic acid (UMMA) levels in patients with HIV infection....
 PDF: doaj.org
Prescription drug use patterns of human immunodeficiency virus-infected patients taking zidovudineABSTRACT: Prescription drug profiles of 116human immunodeficiency virus (HIV)-infected patients taking zidovudine in 1988were surveyed....
International journal of pharma and bio sciences formulation and evaluation of taste masked dispersible tablets of zidovudineZidovudine is an antiretroviral drug commonly used in the treatment HIV infection....
santé - iate.europa.eu
azidothymidine
santé - iate.europa.eu
Mais de nouvelles recherches ont trouvé un peut composé chimique d'origine végétale qui est beaucoup plus efficace que azidothymidine.

But new research may have found a plant-derived chemical compound that is much more effective than azidothymidine.

général - CCMatrix (Wikipedia + CommonCrawl)
Azidothymidine, le premier médicament qui a été approuvé dans la lutte contre le sida dans les années 1980, est toujours un élément principal dans le mélange de médicaments couramment prescrits aux patients atteints du VIH aujourd'hui.

Azidothymidine, the first drug that was approved in the fight against AIDS in the 1980s, is still a main component in the medication mix commonly prescribed to HIV patients today.

général - CCMatrix (Wikipedia + CommonCrawl)
Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive dna synthesis and viral replication....substitutions in the reverse transcriptase (RT), including D67N, K70R, T215Y, and K219Q, cause high-level resistance of human immunodeficiency virus type 1 (HIV-1) to zidovudine (3'-azidothymidine; AZT) and appear to approximate the template strand of the enzyme-template-primer complex in structural models....
santé - core.ac.uk - PDF: www.pubmedcentral.nih.gov
Journal of antimicrobial chemotherapy doi: 10.1093/jac/dkf205 inhibition of murine aids by a heterodinucleotide of azidothymidine andTenofovir [9-(R)-2-(phosphonomethoxypropyl)adenine (PMPA)] and zidovudine [azidothymidine (AZT)] are potent anti-HIV agents that have shown a strong synergy in in vitro studies....
Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha a interferon.Both recombinant alpha A interferon and azidothymidine inhibit the replication of human immunodeficiency virus in peripheral blood mononuclear cells....

Publications scientifiques

In vitro anti-human immunodeficiency virus and anti-hepatitis b virus activities and pharmacokinetic properties of heterodinucleoside phosphates containing azt or ddc... human immunodeficiency virus (HIV)- and hepatitis B virus (HBV)-infected cells, of four amphiphilic heterodinucleoside phosphates containing 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxycytidine (ddC) as antiviral monomers were evaluated....
santé / produit alimentaire - core.ac.uk - PDF: www.zora.uzh.ch
A single zidovudine (azt) administration delays hepatic cell proliferation by altering oxidative state in the regenerating rat liverThe 3′-azido-3′-deoxythymidine or Zidovudine (AZT) was the first antiretroviral drug used in the treatment of HIV patients, which has good effectiveness but also hepatotoxic side effects that include cell cycle...
santé / produit animal / produit alimentaire - core.ac.uk - PDF: doaj.org
Synthesis, in vitro anti-hiv and anti-hepatitis b activities and pharmacokinetic properties of amphiphilic heterodinucleoside phosphates containing ddc and aztAmphiphilic heterodinucleoside phosphates containing AZT and ddC as antiviral monomer were synthesized according to the hydrogenphosphonate method and evaluated in vitro against HIV....
santé - core.ac.uk - PDF: www.zora.uzh.ch
Improved safety, bioavailability and pharmacokinetics of zidovudine through lactoferrin nanoparticles during oral administration in rats.Zidovudine (AZT) is one of the most referred antiretroviral drug....
produit animal / santé / détérioration de l'environnement - core.ac.uk - PDF: doaj.org
Extrahepatic metabolism of zidovudine.The metabolism of zidovudine (3'-azido-3'-deoxythymidine; AZT) has been studied in human renal, gut and hepatic microsomes....
produit animal / santé / détérioration de l'environnement - core.ac.uk - PDF: www.pubmedcentral.nih.gov

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