The mutant herpesvirus can be substantially avirulent and immunogenic.
The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal.
This invention provides a vaccine for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. choleraesuis.
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi.
The avirulent immunogenic mutant can be a transposon-mediated mutant or a mutant having at least one genetically modified virulence gene.
A method of vaccinating poultry by spraying the poultry with an effective amount of a live avirulent derivative of an enteropathogenic enterobacteria is disclosed.
When the antibiotic experiment was repeated using the avirulent Kp-39, there was no mortality.
A vaccine of the invention can be comprised of a stable avirulent immunogenic P. multocida mutant or a recombinantly produced P. multocida virulence factor.
The present invention relates to a live avirulent infectious pancreatic necrosis virus which has been shown to be genetically stable in biological studies.
The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of Haemophilus influenzae (NTHi).
The present invention is a live vaccine against a microbial pathogen that is avirulent, substantially incapable of multiplication in the host, and has no probability for reverting to a virulent wild strain.
Specifically, the present invention provides nucleic acid compounds which encode an avirulence gene product which is capable of causing a hypersensitive response in plants which recognize the gene product.
The methods of the invention include steps of producing an avirulent immunogenic mutant and administering an effective amount of the mutant to protect an animal against P. multocida pasteurellosis.
Immune pressure may result from natural exposure to HBV or following vaccination with an avirulent or attenuated HBV or with a component of an HBV.
The outer membrane proteins can be produced by recombinant means and expressed in an avirulent carrier microbe which may be used to immunize a subject of interest.
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