The roles of microglia-synapse interactions in Alzheimer’s disease

The present invention provides isolated astrocyte derived neurotrophic factor, cDNA encoding same, and uses thereof.

Astrocytes are star-shaped in structure. © Karin Pierre, Institute of physiology, UNIL, Lausanne, European Dana Alliance for the Brain (EDAB)

One type pf glial cell called an astrocyte, removes unnecessary synapses in the brain to remodel its wiring.

Modulators of radial glia-astrocyte differentiation and transformation comprising a secreted radial glial differentiation factor have been identified, isolated, purified and characterized.

It also relates to tissue, astrocyte containing cultures, liver stellate cell containing cultures and cells from said animal.

Why would it be disadvantageous for an astrocyte to synthesize its own fats and cholesterol?

The present invention is directed to therapeutic compositions targeting the NCCa_ATP channel of an astrocyte, neuron or capillary endothelial cell and methods of using same.

Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response.

One kind of glial cell, known as an astrocyte, prunes unnecessary synapses in the brain to redesign its wiring.

One type of glial cell, called an astrocyte, prunes unnecessary synapses in the brain to remodel its wiring.

The genetically modified astrocyte may be produced utilizing plasmids and non-viral transfection methods, as are also provided by the subject invention.

After in vitro embryoid body formation and directed differentiation, aiPSCs formed all three germ layers and all three lineages of neural cells: neuronal, astrocyte and oligodendrocyte.

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses.

In addition, on the basis of this work I am trying to understand whether a modification of the astrocyte-neurone interaction would be involved in certain brain pathologies.