The present invention provides adeno-associated viral (AAV) vectors encoding an angiostatin protein (“AAV-angiostatin vector ”) and/or a constimulatory molecule B7.1 (“AAV-B7.1 vector”).
It is intended to provide a method for producing an angiostatin-like polypeptide from canine plasminogen having a native sugar chain and a canine angiostatin-like polypeptide obtained by this method.
An anticancer agent containing BL angiostatin as an active ingredient; and a process for producing the same.
Administration of AAV-angiostatin and AAV-B7.1 vectors by intraportal and muscular injections are also provided.
Pharmaceutical compositions and vaccines comprising the AAV-angiostatin vector and/or the AAV-B7.1 vector and methods of manufacturing are also described.
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