This invention addresses how to rapidly prevent alphavirus-induced encephalitides before and after exposure to alphaviruses.

Specifically, alphavirus particles are provided having nucleic acid molecules derived from one or more alphaviruses and structural proteins (capsid and/or envelope) from at least two or more alphaviruses.

The present invention also provides the nucleic acids related to said alphavirus, and methods to treat cancer in a mammal using the alphavirus and related nucleic acids.

Also disclosed are attenuated chimearic alphaviruses and their uses.

The invention provides methods of inhibiting alphavirus replication and treating alphavirus infection.

Emerging alphaviruses in the Americas: Chikungunya and Mayaro.

Emerging Alphaviruses in the Americas: Chikungunya and Mayaro.

Ross River virus (RRV) is an arbovirus of the genus Alphavirus.

Another branch of research involving alphaviruses is in vaccination.

Embodiments herein relate to compositions of and methods for live attenuated alphaviruses.

Provided herein are compositions and methods for treating a disease or disorder associated with an alphavirus infection.

Ross River virus (RRV) is an arbovirus of the genus Alphavirus.

Encephalitic alphaviruses (Venezuelan, eastern, and western equine encephalitis viruses)

Use of this chimeric alphavirus for vaccines and in serological and diagnostic assays is also disclosed.

The virus, which is classified as an alphavirus, is similar to dengue virus.