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alniditan

santé / chimie - iate.europa.eu

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H5-ht(1b) receptor-mediated constitutive gα(i3)-protein activation in stably transfected chinese hamster ovary cells: an antibody capture assay reveals protean efficacy of 5-ht... The agonists, 5-HT, alniditan and BMS181,101, stimulated Gα(i3), whereas methiothepin and SB224,289 behaved as inverse agonists....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

No contractile effect for 5-ht(1d) and 5-ht(1f) receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery... Agonists with affinity at the 5-HT(1B) receptor, such as sumatriptan, alniditan and/or IS-159, elicited dose-dependent contraction in both human and bovine cerebral arteries....

PDF: www.pubmedcentral.nih.gov

Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-ht(1b) and 5-ht(1d) receptors expressed in various mammalian cell lines... Alniditan, a novel migraine abortive agent, is a potent 5-HT(1B)/5-HT(1D) receptor agonist of nM affinity....

PDF: www.pubmedcentral.nih.gov

Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar arteryThe non-indole 5-HT receptor agonist, alniditan (R 91274), was tested and compared to sumatriptan in an in vivo model of neurogenic inflammation within the meninges of rats and in rat basilar artery in a Mulvany-Halpern...

PDF: www.loc.gov

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