A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures... Here we show that certain LPLs, particularly lysophos-phatidylcholine and lysophosphatidylinositol, prevent neuronal death both in an in vivo model of transient global ischemia and in an in vitro model of excitotoxicity using primary cultures of cerebellar granule cells exposed to high extracellular concentrations of glutamate (20-40 mol/L)....
Nbqx attenuates excitotoxic injury in developing white matter... In vitro, oligodendrocytes (OLs) express non-NMDA glutamate receptors (GluRs) and are susceptible to GluR-mediated excitotoxicity....
Influences of the circadian clock on neuronal susceptibility to excitotoxicity...SCN2.2 cells (like their in vivo counterpart) are resistant to excitotoxicity by glutamate and that this was dependent on activation of ERK signaling....
Astrocytes regulate glur2 expression in motor neurons and their vulnerability to excitotoxicity... We identified a difference in GluR2 expression in motor neurons from two rat strains, resulting in a difference in vulnerability to AMPA receptor-mediated excitotoxicity both in vitro and in vivo....
