Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.The effect that a 14-day treatment program of total parenteral nutrition (TPN) combined with the glutamine antimetabolite, acivicin, and anabolic hormone, insulin, has on carcass weight and muscle sparing was investigated in tumor-bearing rats...
Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidases.... Acivicin inhibition and binding are prevented by gamma-glutamyl substrates and analogs (e...
Phase i clinical trial of a combination of dipyridamole and acivicin based upon inhibition of nucleoside salvage1A Phase I clinical trial of simultaneous 72-h infusions of dipyridamole and acivicin was carried out in patients with advanced malignancies...
Combined, functional genomic-biochemical approach to intermediary metabolism: interaction of acivicin, a glutamine amidotransferase inhibitor, with escherichia coli k-12... This molecule prevented the growth of Escherichia coli in minimal medium unless the medium was supplemented with a purine or histidine, suggesting that the HisHF enzyme, a glutamine amidotransferase, was the target of acivicin action...
