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Metabolism of a g protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct... Exposure coverage for the major circulating metabo-lites in humans at steady state and in preclinical species used in drug safety assessments was determined by using pooled plasma samples collected from a human multiple ascending dose study and a 3-month rat toxicokinetic study....

santé - core.ac.uk - PDF: dmd.aspetjournals.org

Publications scientifiques

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Toxicokinetics of ergovaline in the horse after an intravenous administration

Étude toxicocinétique de l'ergovaline chez le cheval après injection intraveineuse....

...The toxicokinetics of ergovaline (an ergopeptine mycotoxin present in some grasses infected with endophytic fungus of the genus Neotyphodium) were studied after intravenous administration...

général - core.ac.uk -

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Pharmacokinetic analysis for assessing developmental toxicity of a new synthetic acetolactate synthase inhibitor,... Because these malformations are not common as spontaneous variations in rats, we carried out a toxicokinetic study to clarify whether the fetal anomalies at 500 mg/kg are related to LGC-40863....

général - core.ac.uk - PDF: jpet.aspetjournals.org

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Chronic exposure to deoxynivalenol has no influence on the oral bioavailability of fumonisin b1 in broiler chickens... A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5...

général - core.ac.uk - PDF: biblio.ugent.be

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An analysis of a humidifier disinfectant case from a toxicological perspective... For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted....

général - core.ac.uk - PDF: doaj.org

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Effect of age on toxicokinetics among human volunteers exposed to propylene glycol methyl ether (pgme)... In a controlled human toxicokinetic study (exposure chamber; 12 m³), aging volunteers (n=10; >58 years) were exposed to propylene glycol monomethyl ether (PGME, CAS no....

général - core.ac.uk - PDF: serval.unil.ch