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Optimized armed oncolytic adenoviral vaccines (pepticrad) for an enhanced anti-cancer immune response.... In the present work, we adapted PeptiCRAd in a poor immunogenic and high immunosuppressive tumour model such as TNBC and for the first time we improved the PeptiCRAd platform adding on the same oncolytic vaccine tumour peptides restricted for both MHC-I and MHC-II in order to harm TCD8+ and TCD4+ lymphocytes and to obtain a more efficient and complete immune response....

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A novel fragment derived from the beta chain of human fibrinogen, beta 43-63, is a potent inhibitor of activated endothelial cells in vitro and in vivo...necrosis.Conclusions: Taken together, these data suggest that β43–63 is a novel anti-tumour peptide whose anti-angiogenic effects are mediated by αvβ3

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