Prostacyclin receptor-independent inhibition of phospholipase c activity by non-prostanoid prostacyclin mimetics... The non-prostanoid prostacyclin mimetics, octimibate, BMY 42393 and BMY 45778, also stimulated adenylyl cyclase activity, with EC(50) values of 219, 166 and 398 nM, respectively, but failed to stimulate [(3)H]-inositol...
Octimibate inhibition of platelet aggregation: stimulation of adenylate cyclase through prostacyclin receptor activationOctimibate inhibited ADP- and collagen-induced platelet aggre-gation in human, rabbit and rat platelet-rich plasma....
Prostacyclin agonists reduce early atherosclerosis in hyperlipidemic hamsters octimibate and bmy 42393 suppress monocyte chemotaxis, macrophage cholesteryl ester accumulation, scavenger receptor activity, and tumor necrosis factor productionWe determined the effects of two prostacyclin agonists (octimibate and BMY 42393) on the progression of the fatty streak in vivo and on macrophage function in vitro....
