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sciences naturelles et appliquées - acta.es
This invention provides a nuclease-resistant external guide sequence (EGS) oligonucleotide selected from the group consisting of Inno-1405, Inno-1407 and Bcl-xL1 whose sequences are set forth in Table 1.

L'invention concerne un oligonucléotide de séquence guide externe (EGS) pouvant être Inno-1405, Inno-1407 et Bcl-xL1 (séquences présentées au tableau 1).

santé - wipo.int
Review gene silencing in the therapy of influenza and other respiratory diseases: targeting to rnase p by use of external guide sequences (egs)... This article will review the rationale for the use of External Guide Sequence (EGS) in targeting specific mRNA molecules for RNase P-mediated intracellular destruction....
général - core.ac.uk - PDF: citeseerx.ist.psu.edu
Effective inhibition of human cytomegalovirus gene expression and growth by intracellular expression of external guide sequence rnaRNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression....
Decrease in gyrase a protein expression in _e. coli_ cells inhibited by antisense ribozymesRNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression....
Accelerated publication rnase p as a tool for disruption of gene expression in maize cells...tRNAs (ptRNAs) in all organisms, can be enticed to cleave any target mRNA that forms a ptRNA-like structure and sequence-specific complex when bound to an RNA, termed the EGS (external guide sequence)....
Targeted cleavage of mrna by human rnase p.... RNase P from human (HeLa) cells cannot catalyze the cleavage in vitro of the 5'-proximal oligoribonucleotide that contains the leader sequence in such simple complexes but can do so when the 3'-proximal oligoribonucleotide (external guide sequence) is altered to resemble three-quarters of a tRNA molecule....

Synonymes et termes associés anglais

Exemples anglais - français

sciences naturelles et appliquées - acta.es

Traductions en contexte anglais - français

Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed.

On a synthétisé des molécules de séquences guides externes (SGE) modifiées, qui servent de médiateur dans le clivage d'ARN cibles spécifiques.

santé - wipo.int
External guide sequence (EGS) molecules for eukaryotic RNAse P are engineered to target efficient and specific cleavage of target RNA.

La présente invention concerne l'obtention par génie génétique de molécules EGS ou 'séquences guides externes' (External Guide Sequence) permettant à la ribonucléase P eucariote de cibler le clivage efficace et spécifique d'ARN cible.

santé - wipo.int
The method involves the delivery of external guide sequences, ribozymes, or vectors encoding external guide sequences or ribozymes, to eukaryotic cells.

Ledit procédé consiste en l'apport de séquences guide externes, de ribozymes ou de vecteurs codant des séquences guide externes ou des ribozymes, à des cellules eucaryotes.

santé - wipo.int


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