The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop... Our Molecular Dynamics simulations revealed the formation of a persistent salt bridge between Glu289 on strand s2C and Arg362 on the Reactive Centre Loop (RCL), a region important for the inhibitory activity of NS....
Antithrombin cambridge ii, 384 ala to ser further evidence of the role of the reactive centre loop in the inhibitory function of the serpins ... This is one of a series of conserved alanines that form the stalk to the reactive centre loop....
Reactive centre loop dynamics and serpin specificity... Serpin specificity towards its protease target is dictated by its flexible and solvent exposed reactive centre loop (RCL), which forms the initial interaction with the target protease during inhibition....
Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide ... During this process the exposed reactive-centre loop of PAI-1 is believed to undergo a conformational change becoming inserted into β sheet A of the serpin....
