The vinblastine derivatives comprise hydrazinolyzed vinblastine compounds and vinblastine dipeptide derivatives.
A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.
Thus, vinblastine and vincristine become vinBLAStine and vinCRIStine.
The alkaloid may comprise colchicine, vinblastine, vincristine, a cytochalasin or their derivatives.
Cycloalkyl and aromatic vinblastine and vincristine derivatives useful as anti-tumor agents.
The combination of methotrexate and vinblastine has also been helpful.
Vinblastine is a cytostatic substance with antitumor activity.
The coupling produces anhydrovinblastine and anhydrovinblastine eniminium, which can be transformed to vinblastine or vinorelbine.
The drugs used are Adriamycin, Bleomycin, Vinblastine, and Dacarbazine (DTIC).
To determine 6 month, 12 month and 2 year progression free survival (PFS) between vinblastine alone versus in combination with Bevacizumab.
procarbazine uses in the treatment of Hodgkin’s disease.
Lomustine is also used to treat Hodgkin's disease.
Vincristine, vinblastine and other vinca alkaloids (used to treat cancer)
It is the source of the chemotherapeutic agents: Vincristine, Vinblastine, Vindesine, and Vinrelbine.
The active ingredient of the medicament is an alkaloid such as colchicine, vinblastine, vincristine, a cytochalasin or derivaties thereof.
Vincristine, vinblastine and other vinca alkaloids (used to treat cancer)
These derivatives can be used for avoiding or removing multidrug resistance to antitumour agents, such as vinblastine or adriamycin.
The present invention provides a new kind of vinblastine derivatives, preparation method therefor and application thereof.
Another drug regimen was introduced in 1987 called EBVP (epirubicin, bleomycin, vinblastine, prednisone).
In children, treatment of the systemic forms relies on the combination of corticosteroids and vinblastine.
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