Increasing the antitumor effect of an epcam-targeting fusion toxin by facile click pegylationFusion toxins used for cancer-related therapy have demonstrated short circulation half-lives, which impairs tumor localization and, hence, efficacy....
A recombinant fusion toxin based on enzymatic inactive c3bot1 selectively targets macrophages.... The recombinant C3bot1E174Q-C2I fusion toxin was cloned and expressed as GST-protein in Escherichia coli....
Novel prodrug-like fusion toxin with protease-sensitivebioorthogonal pegylation for tumor targeting... However,despite replacement of the natural cell-binding domain of ETA by tumor-selectiveantibodies or alternative binding proteins like designed ankyrin repeatproteins (DARPins) the therapeutic window of such fusion toxins isstill limited by target-independent cellular uptake, resulting intoxicity in normal tissues....
A recombinant diphtheria toxin related human cd4 fusion protein specifically kills hiv infected cells which express gp120 but selects fusion toxin resistant cells which carry hiv.... The fusion toxin DAB389CD4 possesses enzymatic activity and binds to gp120....
