Disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds.

Provided is a tau aggregation inhibitor which can reduce the tau aggregation in a cell satisfactorily.

Disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds.

Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds.

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The invention also relates to a Tau protein adapted to form a detectable signal when the Tau protein is bound to a Fyn protein.

The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau.

The present invention relates to novel methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association and pathological neurofilament aggregation.

Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught.

Also disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds.

The invention provides for tau antibodies, antibody-like scaffolds or antibody fragments with improved binding capacity for tau antigen.

Tau tau of the wealthy would generally be made of wood from the jackfruit tree.

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The antibody can include an albumin moiety, and targets the removal of antigens such as tau protein, phosphorylated tau (pTau) protein, Ubiquitin and PKN.

Provided is a tau aggregation inhibitor which can satisfactorily inhibit the aggregation of tau in a cell.