Crystalline forms of Sitagliptin salts, processes for preparing crystalline forms of Sitagliptin salts, and pharmaceutical compositions of Sitagliptin salts are provided.
Sitagliptin phosphate monohydrate (CAS RN 654671-77-9
Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates.
Sitagliptin phosphate monohydrate (CAS RN 654671-77-9
Provided is preparation method of R-sitagliptin.
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Following a [14C]sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin.
Sitagliptin is also a substrate of p-glycoprotein, which may also be involved in mediating the renal elimination of sitagliptin.
Following a [14C]sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin.
Following a [14C]sitagliptin oral dose, approximately 16% of the radioactivity was excreted as metabolites of sitagliptin.
They also failed to prove an added benefit for sitagliptin plus sulfonylurea and sitagliptin/metformin (free or fixed combination) plus sulfonylurea.
Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin.
Sitagliptin is a substrate for the transporter of organic human anions of the third type (hOAT-3), which can be involved in the process of releasing sitagliptin by the kidneys.
The absolute bioavailability of sitagliptin is approximately 87%.
Two studies compared the medications sitagliptin to glipizide.
Sitagliptin is a substrate for human organic anion transporter-3 (hOAT-3), which may be involved in the renal elimination of sitagliptin.
Process for the production of sitagliptin orotate (III) in amorphous form is described.
The present invention provides processes for the preparation of amorphous form of sitagliptin dihydrogen phosphate.
The present invention further relates to novel polymorphs of Sitagliptin salts and process for preparation thereof.
Sitagliptin is also a substrate of p-glycoprotein, which can also participate in the process of renal elimination of sitagliptin.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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