The invention provides human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG.

Methods of distinguishing RET-independent GDNF ligand-mediated intracellular signaling by different cellular GDNF receptors from RET-dependent intracellular signaling are provided.

The invention is useful for high throughput screening of molecules and intracellular signalling pathway detection.

Schema representing the intracellular MAPK/ ERK pathway.

The use of such signalling molecules within chimeric receptor proteins allows one to tailor the level of intracellular signalling mediated by the chimeric receptor.

Here it plays a key role in intracellular signalling.

It may also play a role in intracellular signalling.

Methods for assessing libraries of candidate modulators of intracellular signaling transmission pathways are described.

The present invention is based on the functional and structural analysis of a novel RANK signaling motif that was found to play a distinct role in activating RANK-mediated intracellular signaling.

Additional members of the intracellular signaling pathway whose phosphorylation can be measured are also described.

The invention provides human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG.

The invention provides methods for identifying modulators of RETindependent, GDNF effected intracellular signaling.

The present invention relates to compositions and methods useful for detecting and/or measuring, e.g., intracellular signaling in vivo.

These external factors activate intracellular signaling, stimulating cancer cell proliferation.

The invention provides human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG.