immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (IDEXX HerdChek BSE-Scrapie Antigen Test Kit, EIA

immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (IDEXX HerdChek BSE-Scrapie Antigen Test Kit, EIA

immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (IDEXX HerdChek BSE-Scrapie Antigen Test Kit, EIA

Although the scrapie agent is irreversibly inactivated by alkali, five procedures with more specificity for modifying nucleic acids failed to cause inactivation.

In neurons of diseased patients, prion proteins adopt an incorrect conformation, becoming resistant to degradation and aggregate amongst themselves, becoming “scra-pie” proteins, PrPsc.

Hadlow saw the similarities between scrapie in sheep and kuru, described in 1957 by Gajdusek and Zigas in the Fore from Papua-New Guinea.

When farmers first noticed their sheep had an unusual disease affecting their brains, they named it scrapie without understanding that prions were behind the illness.

PrPC is normally present in the nervous system of healthy individuals and is absent in Creutzfeldt-Jakob prion disease patients who have a pathological form of prion protein called scrapie prion protein (PrPSc).

PrPC is ordinarily present in a healthy person’s nervous system, but absent in Creutzfeldt-Jakob prion disease patients who have ‘a pathological form of prion protein called scrapie prion protein (PrPSc).

— the immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (HerdChek BSE-Scrapie Antigen (IDEXX Laboratories)),

— the immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (IDEXX HerdChek BSE-Scrapie Antigen Test Kit, EIA).

In the presence of PrPsc (sc for scrapie, the term used to designate the disease caused by prions in sheep), PrPc undergoes a change in conformation to become an infectious protein itself: a prion.

— the immunoassay using a chemical polymer for selective PrPSc capture and a monoclonal detection antibody directed against conserved regions of the PrP molecule (HerdChek BSE-Scrapie Antigen (IDEXX Laboratories)),

The normal form of the protein is called PrPC, while the infectious form is called PrPSc — the C refers to 'cellular' or 'common' PrP, while the Sc refers to 'scrapie', a prion disease occurring in sheep.

The normal form of the protein is called PrPC, while the infectious form is called PrPSc — the C refers to healthy ‘cellular‘ PrP, while the Sc refers to infectious ‘scrapie‘, the prototypic prion disease, occurring in sheep.

The normal form of the protein is called PrPC, while the infectious form is called PrPSc—the "C" refers to "cellular" PrP, while the "Sc" refers to "scrapie," the prion disease occurring in sheep.