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séglitide

seglitide

chimie / santé - iate.europa.eu

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Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosa.... Irrespective of the secretagogue used to increase acid output, the rank order of potencies was similar (BIM-23027 = seglitide = octreotide > SRIF-14 = SRIF-28 > L-362,855)....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Mediation by srif1 receptors of the contractile action of somatostatin in rat isolated distal colon; studies using some novel srif analogues.... The SRIF peptide analogues, octreotide, SRIF25, seglitide, angiopeptin and CGP23996 (1 nM-1 microM) produced contractile responses in the rat distal colon, each having similar potency and maximal activity relative to SRIF....

PDF: www.pubmedcentral.nih.gov

Antagonist effects of seglitide (mk 678) at somatostatin receptors in guinea-pig isolated right atria.... Here we report that in guinea-pig isolated right atria, seglitide, a potent cyclic hexapeptide somatostatin agonist, behaves as a competitive somatostatin receptor antagonist with pA2 values against SS14, SS25 and SS28, of 6.50...

PDF: www.pubmedcentral.nih.gov

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