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réparation de longues séquences

long-patch base-excision repair

santé - iate.europa.eu

réparation de longues séquences

longpatch repair

santé - iate.europa.eu

Ainsi, l'essai UDS est particulièrement utile pour détecter la réparation de longues séquences (20-30 bases) induite par la substance.

Therefore, the UDS test is particularly valuable to detect substance-induced longpatch repair (20-30 bases).

général - eur-lex.europa.eu

réparation de longues séquences

Human dna polymerase β initiates dna synthesis during long-patch repair of reduced ap sites in dna... How ever, some DNA lesions that render deoxyribose resistant to β-elimination are removed through a long-patch repair pathway that involves strand displacement synthesis and removal of the generated flap by specific endonuclease....

général - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Publications scientifiques

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Dna polymerase b as a novel target for chemotherapeutic intervention of colorectal cancer... First, we determined the specificity of NSC-124854 for Pol-b by examining in vitro activities of APE1, Fen1, DNA ligase I, and Pol-b-directed single nucleotide (SN)-and long-patch (LP)-BER....

santé - core.ac.uk - PDF: ftp:

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Nsc666715 and its analogs block pol-β-directed lp-ber activity.The LP-BER was determined using an in vitro reconstituted assay system....

général - core.ac.uk - PDF: figshare.com

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Nsc-124854 blocks pol-β-directed sn- and lp-ber activities.Panels A and B represent the protocols of the SN- and LP-BER, respectively....

général - core.ac.uk - PDF: figshare.com

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The 9-1-1 complex specifically stimulates the endonuclease activity of ape 1 in lp-ber schematic representation of the substrate used in the lp-ber reaction...2007PMCID:PMC1885638.© 2007 The Author(s) LP-BER assay was performed as described in ‘Materials and Methods’ The reaction mixtures (10 μl) contained (besides all components described in ‘Materials and Methods’) unlabeled...

général - core.ac.uk - PDF: figshare.com

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The model of unique wrn helicase mechanism in ber or lp-ber.(A) Preceding steps in the BER or LP-BER involving glycosylases and APE1 result in gaps in the translocating and non-translocating DNA strands....

général - core.ac.uk - PDF: figshare.com