Perturbations of model membranes induced by pathogenic dynorphin a mutants causing neurodegeneration in human brain... The overall correlation between membrane perturbation and neurotoxic response [3] suggests that pathogenic Dyn A actions may be mediated through transient pore formation in lipid domains of the plasma membrane
Research article c i n background previously reported that mild excitotoxicity produced byCharlottetown, PEI, CanadaDomoic acid (DOM) is an AMPA/kainate receptor ligand that elicits a very rapid and potent neurotoxic response, and as such, has been used as a reliable re-search tool to investigate excitotoxic damage in vivo [1-4] and in vitro [5-7]....
Cellular and molecular responses of cultured neurons to stressful stimuli... Using neuronal experimental systems, we will discuss how compounds with low dose effects mediated via glutamate receptors can result either in a neuroprotective or neurotoxic response....
Printed in (isa. developmental time course and ionic dependence of kainate-The mechanisms associated with the neurotoxic response caused by kainate (KA) were examined in cerebellar granule cell cultures....
