The apparatus comprises an anchor (22) that is adapted to be reconfigured from a reduced delivery profile within a delivery catheter (11) to an expanded deployed profile once the anchor (22) is released from the delivery catheter (11).

Methods and systems for controlling an insulin pump in response to glucose measurements are responsive to a base insulin delivery profile and a temporary insulin delivery profile.

A control system may be utilized to control the desired drug delivery rate/profile.

A constraining sheath can be configured to neck down a medical device to achieve a lower delivery profile.

The metering of the tether by the motor controls the rate or profile of drug delivery to a user.

The invention features an implantable device (10) for the automatic delivery of an active ingredient according to an adjustable delivery profile.

Outside that time range, the insulin amount is determined using the base insulin delivery profile.

The controlled delivery of the composition avoids an initial drug spike, resulting in a smooth delivery profile over time.

The present disclosure presents systems, devices and methods for administration of a therapeutic fluid to the body of a patient at a transient basal delivery profile, and enabling modification of the transient profile.

In particular the present invention relates to altering the pharmacokinetic profile and mode of delivery of these therapeutic compounds by conjugating them to one, two or three acyl derivatives of fatty acids.

The user can set the safety level as a percentage of deviation to the drug delivery profile.

In some cases one layer provides a burst release and the second layer provides a slow release drug delivery profile.

During a selected time range, an insulin amount for the pump to supply is determined using the temporary insulin delivery profile.

Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.

After the old drug is cleared, then the control means automatically modifies the Current Profile data to match a second, or new, delivery profile for controlling delivery of a second, or new, drug.