Viral polymerase inhibitors may then inhibit the readout from the assay.
Further comprised are modified cap-leader sequences that are able to block elongation by the viral polymerase or cleavage by the viral endonuclase.
The present invention provides nucleoside derivatives which are inhibitors of RNA-dependent RNA viral polymerase.
Lamivudine-TP acts as a substrate for the HBV viral polymerase.
NS3 is a putative helicase, and NS5 is the viral polymerase.
The invention herein provides novel viral DNA polymerase compounds.
Aciclo-GTP is a very potent inhibitor of viral DNA polymerase; it has approximately 100 times higher affinity to viral than cellular polymerase.
Aciclo-GTP is a very potent inhibitor of viral DNA polymerase; it has approximately 100 times higher affinity to viral than cellular polymerase.
Aciclovir triphosphate selectively inhibits viral DNA polymerase.
Aciclovir triphosphate selectively inhibits viral DNA polymerase.
Aciclovir triphosphate selectively inhibits viral DNA polymerase.
These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection.
Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
Viral DNA polymerase binds 10–30 times more strongly to AT than the cellular DNA polymerase.
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase.
The present application discloses new compounds able to interfere with the interactions of the PA and PB1 subunits of viral RNA polymerase.
The present invention provides nucleoside aryl phosphoramidates which are precursors to inhibitors of RNA-dependent RNA viral polymerase.
The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase.
The medicament is used in combination with at least one viral DNA-polymerase inhibitor and the at least one RTI and the at least one DNA polymerase inhibitor are present in the form of separated compounds.
Compounds of Formula (I) are useful in methods of inhibiting viral RNA polymerase activity and viral replication.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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