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More particularly, it relates to the stable pharmaceutical compositions comprising tumor necrosis factor receptor Fc fusion protein (TNFR:Fc), phosphate - citrate buffer.

They are primarily water and a citrate (or citrate/phosphate) buffer.

The preferred inert anticoagulant is CPD.

Buffers containing citrate and/or phosphate are preferred.

The buffer may be an acetate buffer, citrate buffer, formate buffer, tartrate buffer, phosphate buffer, glycine-hydrochloric acid buffer, citrate-phosphate buffer, or the like.

Broadly, the compositions include respective sources of phosphate ions, citrate ions, and calcium ions, metal hydroxides, and water, with the molar ratio of citrate ions to phosphate ions in the composition being from about 1.0:1.35 to about 1.0:2.35.

The buffer can be made from a solution that may contain acetate, citrate, citrate-phosphate, maleate, or succinate.

Calcium phosphate (also called tribasic calcium phosphate).

Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof.

The plasticizer is, for example, tributyl phosphate or triethyl citrate.

(ii) added disodium phosphate or sodium citrate, or both.

Preferably the composition is essentially-free of citrate(s) and essentially-free of phosphate(s).

Other Names: creatine monohydrate, creatine phosphate, creatine citrate

Calcium is supplied by a combination of calcium citrate and dicalcium phosphate, the phosphorus is supplied by a combination of dicalcium phosphate and magnesium phosphate, and the magnesium is supplied by magnesium phosphate.

Citrates and polyaspartates act as softening agents and replace the phosphates.