The methods are particularly amenable to protected nucleosides and nucleoside phosphoramidites wherein the nucleosides can be modified.
Nucleoside monophosphates are converted to nucleoside triphosphates by in situ reactions to continuously supply the required nucleoside triphosphates.
The silylated and unprotected nucleosides may be either monomeric nucleosides or the terminal nucleosides of an oligonucleotide or oligonucleotide analog.
One aspect of the present invention relates to modified nucleosides and oligonucleotides comprising such modified nucleosides.
The present invention relates to novel phosponate nucleosides, more specifically to novel phosponalkoxy substituted nucleosides.
Novel nucleosides, process for chemical synthesis of nucleosides and incorporation of the nucleosides into polynucleotides are disclosed.
Artificial nucleosides including 2-methyl-nucleobase-substituted butane-l,3-diol nucleosides are disclosed (formulas I and II). Four different stereoisomers of such nucleosides are possible.
The invention relates to novel nucleosides and nucleoside dimers containing an L-sugar in at least one of the nucleosides, and their pharmaceutical compositions.
The present invention relates to nucleoside analogues and more particularly to labeled nucleoside analogues.
The provided novel pyrimidine nucleoside compounds exhibit antitumor efficacy higher than those of conventional pyrimidine nucleoside compounds.
Modified nucleosides and methods of making and using the nucleosides are disclosed.
The present invention relates to nucleoside derivatives with photo-unstable protective groups of general formula (I). The invention further relates to a method for producing said nucleosides, the use thereof and nucleic acid chips consisting thereof.
The present invention provides bicyclic cyclohexose nucleoside analogs and oligomeric compounds comprising these nucleoside analogs.
Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.
A novel class of pharmaceutically active boronated nucleosides are provided.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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