The inventive compounds are preferably embodied in the form NPY antagonists, and more particularly in the form of NPY Y1 subtype antagonists and, whereby are usable in therapeutic or prophylactic treatment all NPY involving disorders.
Certain diarylimidazoles act as partial agonists or antagonists for NPY receptors, in particular NPY 5 receptors.
The present invention provides a novel molecule which inhibits the biological activity of neuropeptide tyrosine (NPY).
In particular, this invention provides human and rat NPY/PYY receptors (which we call the NPY Y5 receptor) and nucleic acids.
The compounds according to the invention are preferably NPY antagonists, and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving NPY.
These compounds act against the binding of the neuropeptide Y (NPY) to the Y5-receptor subtype (NPY-antagonism), and might be used in particular for the treatment of adiposity.
These compounds have in particular a certain affinity for neuropeptide Y, NPY, biological receptors, and more particularly for NPY Y1 receptors, present in the central and peripheral nervous systems.
The present invention relates to selective neuropeptide Y (NPY) Y1 receptor antagonists.
Administration of a suitable DP IV inhibitor leads as a causal consequence to a reduced degradation of the neuropeptide Y (NPY) in the brain of mammals.
This invention relates to method for reducing stress-induced overproduction of neuropeptide Y (NPY) in an individual, said method being aimed to modulate an overactive NPY system in said individual.
They represent valuable NPY-antagonistic active substances.
Importantly, by methods of the invention, both NPY 1-36 and NPY 3-36 can be quantified simultaneously, separately, and independently in a sample that contains both peptides.
A pharmaceutical composition for the treatment of human reproductive disorders which comprises an effective amount of an NPY-Y4 rerceptor ligand.
The present invention provides an expression system of a human NPY receptor gene, comprising e.g. intron IV of the human NPY receptor Y1 gene, or functional variants of the said intron.
Provided are methods of detecting the presence or amount of NPY 1-36 or NPY 3- 36 in a sample using mass spectrometry.
The present invention is directed to benzoxazole compounds which are ltgands at the NPY Y5 receptor.
This compound is useful as an agent for the treatment of various diseases associated with NPY.
Disclosed is a novel compound having an antagonistic activity against an NPY Y5 receptor.
There is provided the use of an NPY antagonist in the manufacture of a medicament for aiding diuresis.
This invention is directed to alkyl sulfonamide derivatives which are ligands at the NPY Y5 receptor.
The disclosure also relates to a NPY/AgRP double knockout mouse which can be used to select for and test potential modulators (e.g., agonists or antagonists) of AgRP and/or NPY.
Provided is a novel compound having NPY Y5 receptor antagonistic activity.
The present invention provides NPY-5 receptor antagonists having a Formula (IA).
In certain embodiments, because the methods of the invention are specific for both NPY 1-36 and NPY 3-36, the methods provide a major advantage over existing immunoassays.
The compounds are useful as agents for the treatment of various diseases associated with NPY.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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