Compositions and methods for reducing the level of nornicotine and N'- nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided.

In yet another embodiment, a lozenge contains (i) at least one of anatabine, anabasine, and nornicotine, and (ii) a therapeutically effective amount of a silver salt.

Other primary metabolites include nicotine N'-oxide, nornicotine, nicotine isomethonium ion, 2-hydroxynicotine and nicotine glucuronide.

Compositions and methods for reducing the level of nornicotine and N'-nitrosonornicotine (ΝΝΝ) in tobacco plants and plant parts thereof are provided.

Compositions and methods for reducing the level of nornicotine and N'-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided.

The present invention generally relates to methods and materials involved in producing tobacco plants having reduced levels of conversion of nicotine to nornicotine.

The list of all these active ingredients is quite long, but the principal alkaloids are nicotine, nornicotine, anatabine, anabasine and myosmine.

An individual may have reasons to consult their doctor due to contra-indications for WTAs (nornicotine may interfere with prednisone).

The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity.

There are possible contra-indications for WTAs, such as the possibility of interaction with meds such as prednisone / prednisolone (the WTA nornicotine has been implicated here).

The other nicotine and tobacco derivatives responsible for cravings (cotinine, anabasin and nornicotins) can be eliminated much longer in certain organs of the body, such as kidney or adipose tissue.

The other nicotine and tobacco derivatives, which are responsible for cravings (cotinine, anabasin and nornicotines) are much longer to eliminate in certain organs of the body, such as kidneys or adipose tissue.