A children’s oncology group phase i studyThe purpose of this study was to determine the dose-lim-iting toxicities, maximum tolerated dose, pharmacokinet-ics, and intratumor and brain distribution of motexafin gadolinium (MGd) with involved field radiation therapy in children with newly diagnosed intrinsic pontine gliomas....
Motexafin gadolinium (gd-tex) selectively induces apoptosis in hiv-1 infected cd4+ t helper cellsHere, we show that motexafin gadolinium (Gd-Tex), a compound that promotes intracellular oxidative stress, selectively induces apoptosis in HIV-1-infected CD4(+) T cells in IL-2-stimulated cultures...
Phase i drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment procedural and long-term resultsBackground—Motexafin lutetium (MLu; Antrin) is a photosensitizer that is taken up by atherosclerotic plaque and concentrated within macrophages and vascular smooth muscle cells....
Phase i trial of motexafin gadolinium in combination with docetaxel and cisplatin for the treatment of non-small cell lung cancer IntroductionMotexafin gadolinium is a novel antineoplastic drug that disrupts cancer cell antioxidant systems, thus contributing to cellular death....
