The chimeric molecule is expressed in a human NK92 cell.
The invention also provides a chimeric molecule comprising a viral-specific ligand and a bacterial-specific ligand.
A preferred chimeric molecule according to the invention is a chimeric molecule in which a protein import sequence (i.e., a HIV tat peptide) is linked to a Fab directed against a viral pathogen, such hCMV.
In addition, methods of making, methods of using, and compositions comprising a chimeric molecule of the invention are provided.
The present invention provides a chimeric molecule comprising a VWF protein fused to a heterologous moiety via a VWF linker.
A chimaeric molecule comprising a therapeutic agent and a chemokine receptor molecule or portion thereof.
The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
The present invention further contemplates the use of the isolated IL-12 or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
The ubiquitin can be modified to replace one or more lysine residues with another amino acid to reduce the amount of ubiquitination and proteasomal degradation of the chimeric molecule.
The invention also relates to compositions comprising the chimeric molecule defined herein and relates to the use of these chimeric molecules especially to trigger cytotoxic activity toward cells sensitive to FasL.
The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising an NKG2D portion and an Fc portion, which binds one or more NK.G2D ligands.
CARs are constructed by assembling domains from different proteins, each of which enables the chimeric molecule to carry out specific functions.
The chimeric molecule can further comprise a polypeptide chain comprising a FVIII protein and a second heterologous moiety, wherein the chain comprising the VWF protein and the chain comprising the FVIII protein are associated with each other.
The chimeric molecule can further comprise a polypeptide chain comprising a FVIII protein and a second heterologous moiety, wherein the chain comprising the VWF protein and the chain comprising the FVIII protein are associated with each other.
A chimeric molecule is produced, which comprises an extracellular domain of mouse Fcγ R3 or mouse Fcγ R4 fused to a transmembrane domain and an intracellular domain of human γ chain or human Fcγ R3.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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