The probes can be polynucleotide or polypeptide probes.

The oligonucleotide probes comprise complementary probes to the miRNAs in the serum miRNA sample and mismatch probes having mismatches from the complementary probes as well as control spike in probes.

The probes in the probe set are detectably labeled.

Also provided are related probes, probe/primer sets and related reagents, kits and methods and also solid reagents comprising primers and/or probes of the invention.

Also provided are related probes, probe/primer sets and related reagents, kits and methods and also solid reagents comprising primers and/or probes of the invention.

In some examples, the probes are gene locus probes and/or chromosomal enumeration pericentromeric probes.

Methods of using the disclosed probes and kits including the probes and/or reagents for producing or using the probes are also disclosed.

The probes are time aligned by detecting when one of the probes generates a trigger, and timing the other probes to stop acquisition simultaneously so the data is synchronized among the probes.

After the quantitative release of the probes, the individual probes can be amplified and recorded.

The probes are directed at a central point above the probe group.

The probes, or nucleic acids encoding the probes, may be delivered to cells or organisms.

The probes pass through a first or upper probe guide retainer which has a plurality of slot sized to receive the probes in a way that they cannot rotate.

The probes (3) are rotatably supported.

Inventive compositions, methods and devices aid in diminishing the effects of infection in the catheters and occlusion of the catheters.

The probes may be oligionucleotides.