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immunosurveillance

immunosurveillance

santé - iate.europa.eu
Depuis sa création, l'idée de immunosurveillance était très controversée.

From its inception, the idea of immunosurveillance was quite controversial.

général - CCMatrix (Wikipedia + CommonCrawl)
Le concept de immunosurveillance a été proposé dans les années 1950.

The concept of immunosurveillance was proposed back in the 1950s.

général - CCMatrix (Wikipedia + CommonCrawl)
Il ya des données limitées mais intéressantes sur l'amélioration de l'hormone de croissance Natural Killer (NK) et l'activité des cellules immunosurveillance des cellules néo-plastique», dit Lopez.

There's some limited yet interesting data on hGH improving Natural Killer (NK) cell activity and immunosurveillance of neo-plastic cells," says Lopez.

général - CCMatrix (Wikipedia + CommonCrawl)
Chez l’animal, les UV-B peuvent influencer le cours de maladies cutanées infectieuses, comme l’onchocercose, la leishmaniose et la dermatophytose, et entraver l’immunosurveillance des cellules épidermiques transformées, précancéreuses.

UVB in animal studies can affect the course of infectious skin diseases, such as onchocerciasis, leishmaniasis and dermatophytosis, and impair immunosurveillance of transformed, precancerous epidermal cells.

général - CCMatrix (Wikipedia + CommonCrawl)
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Role of type 1 conventional dendritic cells in cancer immunosurveillance
...C57BL/6.Nous avons montré que les cDC1, les interférons, les lymphocytes T CD4+ conventionnels et CD8+, et plus tard les lymphocytes NK/NKT, sont cruciaux pour l'immunosurveillance du cancer du sein....
...mice.We have shown that cDC1, interferons, conventional CD4+ and CD8+ T cells and later NK/NKT cells are instrumental in breast cancer immunosurveillance....
général - core.ac.uk -
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Caractérisation des variations fonctionnelles des cellules nk entre deux lignées murines
Les cellules tueuses naturelles (NK) font partie du système immunitaire inné etparticipent activement à l’immunosurveillance antivirale et antitumorale....
...Natural killer (NK) cells are potent innate lymphoid cells that play an important role inboth tumoral immunosurveillance and viral clearance by producing vast amounts of cytokinesand cytotoxic effectors and by expressing death ligands on their surface....
général - core.ac.uk -
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The role of march1 in the b16 melanoma model
Les mécanismes de l’immunosurveillance des tumeurs commencent à être compris et sont appuyés par un multitude de données expérimentales et cliniques....
...The mechanisms of cancer immunosurveillance are beginning to be understood and the concept is being supported by tremendous experimental and clinical data....
général - core.ac.uk -
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Research article clinical significance of langerhans cells in squamous cell carcinoma of the larynx... Langerhans cells (LCs) may be involved in the immunosurveillance against tumors as antigen-presenting cells....
santé - core.ac.uk - PDF: ftp:
Development of human t-cell leukemia virus type 1-transformed tumors in rats following suppression of t-cell immunity by cd80 and cd86 blockade... Our results suggest that HTLV-1-specific cell-mediated immunity plays a critical role in immunosurveillance against HTLV-1-transformed tumor development in vivo
 PDF: www.pubmedcentral.nih.gov
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokinesDuring organogenesis, immunosurveillance, and inflammation, chemokines selectively recruit leukocytes by activating seven-transmembrane-spanning receptors....
 PDF: www.pubmedcentral.nih.gov
Nivolumab in the treatment of metastatic squamous non-small cell lung cancer: a review of the evidence... An improvement in the understanding of tumor immunosurveillance has resulted in the development of the immune checkpoint inhibitors such as nivolumab....
 PDF: doi.org
Restricting glycolysis preserves t cell effector functions and augments checkpoint therapyTumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance....
 PDF: epub.uni-regensburg.de

Publications scientifiques

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Le stress protéotoxique : le prix à payer pour la tolérance au soi immunitaire
...
... This so-called thymic involution increases the susceptibility to infections and autoimmune diseases and impairs response to vaccines and cancer immunosurveillance....
général - core.ac.uk -
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L'absence de cd226 caractérise des lt cd8+ hyporépondeurs au tcr et aux fonctions antitumorales défectueuses
...CD8+ cytotoxic T lymphocytes (CTL) are key immune cells that play an important role in the control of tumor development through their ability of killing cancer cells. However, cancer cells can frequently escape CD8 T-cell recognition and cytolytic functions through the engagement of inhibitory receptors such as CTLA-4 and PD-1. Although immune checkpoint blockade (ICB) such as monoclonal antibody (mAb) anti-PD-1 has represented a promising cancer therapy in cancer care, clinical responses are not observed in the majority of cancer patients. Therefore, elucidating the mechanisms of this lack of responsiveness and finding additional signals that regulate CD8+ T cell anti-tumor functions has become a major priority. While most of the experimental strategy mainly focus on the identification of additional inhibitory receptors, the importance of coactivating receptors in the antitumor CD8+ T cell functions and ICB efficacy remains to be better investigated. Initially described as an adhesion molecule, CD226 (DNAM-1) is co-activating receptor expressed by NK cells and CD8+ T cells that stimulate the secretion of pro-inflammatory cytokines and release of cytolytic granules towards target cells....
général - core.ac.uk -

Traductions en contexte français - anglais

valider des technologies pouvant servir à l’évaluation clinique de produits de BioCanRx (p. ex. imagerie, validation de biomarqueurs, immunosurveillance)

validation of technologies that may apply to clinical evaluation of BioCanRX products (e.g., imaging, biomarker validation, immunological monitoring)

général - CCMatrix (Wikipedia + CommonCrawl)


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