Total synthesis of a streptococcus pneumoniae serotype 12f cps repeating unit hexasaccharide... pneumoniae serotype 12F CPS hexasaccharide repeating unit that is not contained in currently used glycoconjugate vaccines is the assembly of the trisaccharide β-D-GalpNAc-(1→4)-[α-D-Glcp-(1→3)]-β-D-ManpNAcA,...
Synthesis of a hexasaccharide partial sequence of hyaluronan for click chemistry and moreIn the present work, the synthesis of a hexasaccharide partial sequence of hyaluronan equipped with a terminal azido moiety is reported....
Nonionic block polymer surfactants enhance immunogenicity of pneumococcal hexasaccharide-protein vaccines.Incorporated in oil-in-water emulsions, nonionic block polymer surfactants change the kinetics of generated antibody responses against pneumococcal hexasaccharide-protein conjugates: prolonged immunoglobulin M and immunoglobulin G responses are realized....
Synthesis and biological evaluationof a unique heparinmimetic hexasaccharide for structure–activity relationshipstudies...goal.The synthesis of three heparin mimetic hexasaccharides with distinctstructural patterns is described herein, and the influence of thetargeted substitution on their bioactivity profiles is studied using in vitro affinity...
