The present invention relates to replication-defective hepadnaviruses.
These compounds may particularly be used alone or in combination with other drugs for the treatment of the following: hepadnaviruses, flaviviruses, herpesviruses and human immunodeficiency virus.
Some examples for DNA viruses are Herpes viruses, poxviruses, hepadnaviruses and hepatitis B.
The invention features a method of inhibiting the replication of a naturally-occurring hepadnavirus, e.g., hepatitis B virus (HBV), by introducing into proximity with the hepadnavirus a nucleic acid that encodes a hepadnavirus mutant polypeptide.
The virus belongs to the family of hepadnaviruses, it contains deoxyribonucleic acid (DNA), the molecule of which is constantly being completed using the DNA polymerase enzyme.
Methods of identifying compounds having anti-viral activity against Hepatitis B Virus (HBV) and other hepadnavirυses are disclosed.
The enzymatically active composition of matter is used in rapid in vitro assays to screen potential anti-hepadnaviral agents.
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