Also provided are methods of decreasing expression of a PDGF gene in a cell or in a subject to treat a PDGF -related disease.
The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing PDGF gene expression.
The invention relates to antibodies binding to the PDGF-C antigen and capable of inhibiting binding of PDGF-C to the PDGFRα receptor and of inhibiting PDGFRα activation by PDGF-C. Applications of such antibodies are also disclosed.
One way to create such a research organism is to delete exon 4 of the PDGF-B gene.
They tested this in cells and found that, indeed, HIF-1 protein binds to the PDGF-B gene and turns it on.
A closer look at the DNA sequence around the PDGF-B gene showed regions of DNA known to be recognised and bound by the HIF-1 protein.
A closer look at the DNA sequence around the PDGF-B gene showed regions of DNA known to be recognized and bound by the HIF-1 protein.
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