For most substances suspected of being corrosive, further in vivo testing is normally not necessary.
When any result of an in vivo study in somatic cells is positive, in vivo testing for germ cell effects may be justified.
When any result of an in vivo study in somatic cells is positive, in vivo testing for germ cell effects may be justified.
All information on a substance relevant to its potential ocular irritation/corrosivity should be evaluated prior to considering in vivo testing.
Before any in vivo testing for serious eye damage/eye irritation is carried out, all existing information on a substance shall be reviewed.
An in vivo assay is also useful for further investigation of a mutagenic effect detected by an in vitro system.
Atorvastatin was negative for mutagenic and clastogenic potential in a battery of 4 in vitro tests and 1 in vivo assay.
in vivo test in mammalian species.
In vivo test in rabbits (Steps 8 and 9): in vivo ocular testing should begin with an initial test using one animal.
An in vivo test is also useful for further investigation of a mutagenic effect detected by in vitro test.
MUTAGENICITY — IN VIVO MAMMALIAN ERYTHROCYTE MICRONUCLEUS TEST
In vivo test in rabbits (Steps 7 and 8).
MUTAGENICITY — IN VIVO MAMMALIAN ERYTHROCYTE MICRONUCLEUS TEST
Initial test (in vivo eye irritation/corrosion test using one animal
MUTAGENICITY — IN VIVO MAMMALIAN BONE MARROW CHROMOSOME ABERRATION TEST
MUTAGENICITY — IN VIVO MAMMALIAN BONE MARROW CHROMOSOME ABERRATION TEST
UNSCHEDULED DNA SYNTHESIS (UDS) TEST WITH MAMMALIAN LIVER CELLS IN VIVO
This in vivo test provides a method for investigating genotoxic effects of chemicals in the liver.
Justification for the use of another in vivo test shall be provided.
This in vivo experiment is an essential step in the validation process of our products.
If the in vitro cytogenetic test is positive, an in vivo test using somatic cells (metaphase analysis in rodent bone marrow or micronucleus test in rodents) must be conducted.
If the in vitro cytogenetic test is positive, an in vivo test using somatic cells (metaphase analysis in rodent bone marrow or micronucleus test in rodents) must be conducted.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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