Ergometrine also interferes with the process of placental separation, increasing the chance of partial separation.

Adverse effects of vomiting, nausea and hypertension were more likely to be associated with the use of ergometrine-oxytocin.

o ergot alkaloids (eg dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) due to an increased risk of ergotism and other serious vasospastic adverse events

Randomised trials comparing ergometrine-oxytocin use with oxytocin use in women having the third stage of labour managed actively.

Ergometrine-oxytocin (Syntometrine®) is more effective than oxytocin (Syntocinon®) in reducing blood loss during the delivery of the placenta, but has more side-effects.