The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine and 3'-fluoro-3'-deoxythymidine.
In some embodiments, the 3' cap is an inverted deoxythymidine.
Illustrative are 3'-Azido-3'-deoxythymidine-5'-monophosphate-D,L-3 octadecanamido-2-ethoxypropane and 3'-Azido-3'-deoxythymidine-5' butyrate-η-N,N,N-trimethyl-ammonium-β-(1-phospho-2-ethoxy-3-hexadecyloxypropane).
Fluorothymidine is an analogue of the nucleoside thymidine (deoxythymidine).
The nanoparticles have one or more attached sensing moieties comprising one or more uridine 5'-triphosphate groups, 2'-deoxythymidine 5'-triphosphate groups, etc..
The triphosphate derivative acts as a substrate for the HIV reverse transcriptase.
Expression of human cN-IA decreases the efficacy of antineoplastic drugs and increases the toxicity of AZT.
The invention also relates to a method for producing said compounds and to the use thereof for synthesising 3'-[?18¿F]-fluoro-3'-deoxy thymidine.
Methods for preparation of 2',3'-dideoxynucleotides support structures, such as 2',3'-dideoxyguanosine, 2',3'- dideoxyadenosine, and 3'-deoxythymidine support structures are disclosed.
The present invention is directed to methods for treating HIV infections by administering 3'-azido-3'deoxythymidine (zidovudine) in alternative dosing regimens, preferentially once daily.
Said composition can be produced by two ways: by condensation of 3'-azido 3'- deoxythymidine (AZT, II) with choline phosphate, or by interaction between monophosphate AZT (III) and choline.
The anti-retroviral agent is preferably 3'-azido-3'-deoxythymidine and the tea polyphenol compound is selected from tea catechins, theaflavins, thearubigins and combinations thereof.
Immunoassay techniques for quantitating the amount of 3'-amido-3'-deoxythymidine (AMT) in body fluid samples, and antibodies useful in performing such immunoassays, are provided.
A pharmaceutical composition comprising 3'-azido-3'-deoxythymidine and (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one suitable for once daily administration.
A chain-termination type DNA sequencing method is disclosed wherein deoxynucleotide 2'-deoxythymidine-5'-triphosphate is replaced by 2'-deoxyuridine-5'-triphosphate, or analogs thereof.
A reverse transcriptase inhibitor such as 3'-azido-3'-deoxythymidine is used for the treatment or prophylaxis of a retrovirus-associated carcinoma such as breast cancer in a human.
The invention relates to a novel composition 5' choline phosphate 3'-azido 3'-deoxythymidine of formula (I) which exhibits an antiviral action, first and foremost against a human immunodefficient virus (HIV).
Also disclosed is a method for producing 4'-ethynyl-2',3'-didehydro-3'-deoxythymidine or analogue compounds thereof, wherein glycosylation and deprotection are carried out.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Traduction Translation Traducción Übersetzung Tradução Traduzione Traducere Vertaling Tłumaczenie Mετάφραση Oversættelse Översättning Käännös Aistriúchán Traduzzjoni Prevajanje Vertimas Tõlge Preklad Fordítás Tulkojumi Превод Překlad Prijevod 翻訳 번역 翻译 Перевод