The non-canonical deoxynucleoside triphosphate is incorporated into the synthesized DNA in place of a portion of only one canonical deoxynucleoside triphosphate.
Aspects of the invention provide novel and surprisingly effective methods for the detection of nucleic acids, comprising nucleic acid amplification using base-modified deoxynucleoside 5'-triphosphates (dNTPs).
A mutant of mini-vRNAP has been generated that incorporates deoxynucleoside triphosphates.
A use for a deoxynucleoside/nucleoside combination in the preparation of a medicament that fights tumors.
The main content of the caterpillar seems to be a 3'-deoxynucleoside called cordycepin .
The invention concerns phospholipid derivatives of desoxynucleosides, the derivatives consisting of a lipid unit with a substituted C3 base structure linked via a phosphate or thiophosphate to the desoxynucleoside.
First, dFdCDP inhibits ribonucleotide reductase, which is uniquely responsible for catalysing the reactions that produce deoxynucleoside triphosphates (dCTP) for DNA synthesis.
A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a ß-L-2'deoxynucleoside or its pharmaceutically acceptable salt, ester or prodrug.
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