Standard: > 90% reduction in urinary free cortisol

Standard -- greater than 90% reduction in urinary free cortisol

Standard -- greater than 90% reduction in urinary free cortisol

Standard: > 90% reduction in urinary free cortisol

Standard — greater than 90% reduction in urinary free cortisol

Sequential Measurements of Plasma CRH, ACTH, Cortisol, Aldosterone and Urinary Free Cortisol during Pregnancy:

What affects the results of the cortisol 24-hour urine test?

A cortisol urine test is also called a urinary free cortisol test or UFC test.

24-hour urinary free cortisol level: Patient’s urine is collected over 24 hours and examined for the level of cortisol.

Urinary free cortisol (UFC) levels were normalised in about 50% of patients on ketoconazole.

Moreover, those results were correlated by a decrease in urinary free cortisol levels, a biomarker for stress.

At treatment initiation, 24-hour urinary free cortisol should be controlled every few days/weeks.

Ketoconazole HRA daily dose should be periodically adjusted on an individual basis with the aim to normalise urinary free cortisol and/or plasma cortisol levels.

Serum or plasma and/or salivary cortisol and/or urinary free cortisol levels should be monitored, within one week following Ketoconazole HRA initiation as a minimum, and then periodically thereafter.

UFC is elevated > 120 µg/24h (>331 nmol/24h) in almost all patients with Cushing’s syndrome.