Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another anantiomer of clopidogrel are provided.
The present invention relates to an improved process for the preparation of Clopidogrel bisulfate Form I from clopidogrel free base.
Clopidogrel free base is isolated from Clopidogrel acid addition salt.
Provided is clopidogrel base suitable for pharmaceutical formulation, and processes for its preparation.
Clopidogrel acid hydrochloride (CAS RN 144750-42-5
First, clopidogrel is converted into an intermediate metabolite of 2-oxo-clopidogrel.
Clopidogrel is first metabolised to a 2-oxo-clopidogrel intermediate metabolite.
Clopidogrel (Plavix, Zyllt, Zylagren, Zopya, Iscover, Grepid, Clopidogrel Winthrop, Clopidogrel Acino): to be used for a period of 14 days, in combination with acetylsalicylic acid.
First clopidogrel is transformed to a transitional metabolite 2-oxo-clopidogrel.
Crystalline and amorphous forms of clopidogrel napsylate are useful in the preparation of dosage forms of the antithrombotic agent, clopidogrel.
The clopidogrel camphor sulfonic acid can be present in a residue from separating a clopidogrel camphor sulfonic acid optical isomer.
The active substance in Clopidogrel Winthrop, clopidogrel, is an inhibitor of platelet aggregation.
The invention relates to a process for the preparation of form I clopidogrel hydrogen sulfate through suspending clopidogrel hydrogen sulfate in an alkane.
The solution comprises a pharmaceutically acceptable salt of clopidogrel and a substantially non-aqueous agent in which the clopidogrel salt is substantially or completely soluble.
The present invention discloses a process for the preparation of clopidogrel.
Said compounds are intermediates in the synthesis of clopidogrel.
The present invention encompasses processes for the preparation of optically pure clopidogrel camphorsulfonic acid salt without the need to isolate or recover (±) clopidogrel.
Salts of the active ingredient clopidogrel with polyanions are described.
First, clopidogrel is converted into an intermediate metabolite of 2-oxo-clopidogrel.
Clopidogrel/Acetylsalicylic acid Mylan contains two active substances, clopidogrel and acetylsalicylic acid (also known as aspirin) and is a ‘generic medicine’.
Requêtes fréquentes français :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
Requêtes fréquentes anglais :1-200, -1k, -2k, -3k, -4k, -5k, -7k, -10k, -20k, -40k, -100k, -200k, -500k, -1000k,
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