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cellule présentatrice d'antigènes

Immune response gene function correlates with the expression of an ia antigen. ii. a quantitative deficiency in a(e):e(a), complex expression causes a corresponding defect in antigen-presenting cell function... These functional data, in concert with the biochemical and serological data in the accompanying report, are consistent with the molecular model for Ir gene complementation in which appropriate two-chain Ia molecules function at the antigen-presenting cell (APC) surface as restriction elements....

santé / production - core.ac.uk - PDF: www.pubmedcentral.nih.gov

Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics... The hypothesis is that PLP-BPI binds simultaneously to major histocompatibility complex-II and intercellular adhesion molecule-1 on the antigen-presenting cell (APC) and inhibits the formation of the immunological synapse during T-cell and APC interactions....

PDF: www.pubmedcentral.nih.gov

Ia expression by vascular endothelium is inducible by activated t cells and by human gamma-interferonT helper cells recognize exogenous antigens in association with class II histocompatibility antigens (Ia antigens) on the surface of an antigen-presenting cell (APC) 1 (reviewed in reference 1)....

PDF: citeseerx.ist.psu.edu

Publications scientifiques

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Expression and manipulation of the apc-β-catenin pathway during peripheral neuron regeneration... β-catenin was expressed in neuronal nuclei, neuronal cytoplasm and also in perineuronal satellite cells....

santé - core.ac.uk - PDF: link.springer.com

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Tumorigenic fragments of apc cause dominant defects in directional cell migration in multiple model systems... Here we show that, in three distinct experimental model systems, expression of an N-terminal fragment of APC (N-APC) results in loss of directionality, but not speed, of cell motility independently of changes in β-catenin regulation....

santé / détérioration de l'environnement - core.ac.uk - PDF: doaj.org

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Identification of 5 novel germline apc mutations and characterization of clinical phenotypes in japanese patients with classical and attenuated familial adenomatous polyposis.... An attenuated form of FAP (AFAP) is diagnosed based on a milder colorectal phenotype, and the colorectal phenotype of (A)FAP has been linked to germline APC mutations....

santé - core.ac.uk - PDF: hikumano.hama-med.ac.jp

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Antitumor activity of the mek inhibitor trametinib on intestinal polyp formation in apc[δ716] mice involves stromal cox-2Extracellular signal-regulated kinase is an MAPK that is most closely associated with cell proliferation, and the MEK/ERK signaling pathway is implicated in various human cancers....

santé - core.ac.uk - PDF: repository.kulib.kyoto-u.ac.jp

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A target-selected apc-mutant rat kindred enhances the modeling of familial human colon cancer... We have investigated whether a rat model carrying a knockout allele in the gatekeeper gene Adenomatous polyposis coli (Apc) recapitulates familial colon cancer of the human more closely than existing murine models....

Dictionnaire français - anglais

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